Pepsin, enzyme yamphamvu yomwe ili m’madzi am’mimba amene amagaya mapuloteni monga a nyama, mazira, njere, kapena mkaka.Pepsin ndi mawonekedwe okhwima a zymogen (mapuloteni osagwira) pepsinogen.

Pepsinadadziwika koyamba mu 1836 ndi katswiri wa sayansi ya zakuthambo waku Germany Theodor Schwann.Mu 1929 mawonekedwe ake a crystallization ndi mapuloteni adanenedwa ndi American biochemist John Howard Northrop wa Rockefeller Institute for Medical Research.(Kenako Northrop adalandira gawo la 1946 Nobel Prize for Chemistry chifukwa cha ntchito yake yoyeretsa bwino ndi kuyeretsa ma enzyme.)

Tizilombo mu mucous-membrane akalowa m'mimba kupanga ndi kusunga pepsinogen.Impulses kuchokera ku vagus minyewa ndi mahomoni a secretin a gastrin ndi secretin amathandizira kutulutsidwa kwa pepsinogen m'mimba, komwe kumasakanikirana ndi hydrochloric acid ndikusinthidwa mwachangu kukhala puloteni yogwira pepsin.M'mimba mphamvu ya pepsin kwambiri pa acidity ya yachibadwa chapamimba madzi (pH 1.5-2.5).M'matumbo am'mimba acids amachepetsedwa (pH 7), ndipo pepsin sagwiranso ntchito.

M'matumbo a pepsin amangowonongeka pang'ono chabe mapuloteni kukhala timagulu ting'onoting'ono totchedwa ma peptides, omwe amatengeka kuchokera m'matumbo kupita m'magazi kapena amawonongekanso ndi ma pancreatic enzymes.

Ma pepsin ochepa amachoka m'mimba kupita m'magazi, komwe amaphwanya zidutswa zazikulu, kapena zosagawika pang'ono, za mapuloteni omwe angakhale atatengedwa ndi matumbo aang'ono.

Kubwerera kwa pepsin, asidi, ndi zinthu zina kuchokera m'mimba kupita kummero kumapanga maziko a matenda a reflux, makamaka matenda a reflux a gastroesophageal ndi laryngopharyngeal reflux (kapena extraesophageal reflux).Pamapeto pake, pepsin ndi asidi zimayenda mpaka ku kholingo, komwe zimatha kuwononga mphuno ya laryngeal ndikutulutsa zizindikiro kuyambira kutsokomola ndi chifuwa chosatha mpaka laryngospasm (kukomoka kwa zingwe zapakhosi) ndi khansa yapakhosi.

Deebio's pepsinamachotsedwa ku mucosa yapamwamba ya nkhumba ya m'mimba mwaukadaulo wathu wokhawokha.Amagwiritsidwa ntchito kwambiri chifukwa cha dyspepsia yomwe imayamba chifukwa cha kumwa kwambiri zakudya zama protein.

Kwa zaka 30 zakufufuza kafukufuku wa sayansi ndi machitidwe a mafakitale, takhazikitsa "DEEBIO 3H Technology" yapadera, pogwiritsa ntchito njira yonse ya chitetezo cha enzymatic.Tekinoloje yoyang'anira makiyi, kupyolera mu kutsegula kosawononga, kudzutsa zymogen, ndikuzindikira ntchito yayikulu, kuyera kwambiri komanso kukhazikika kwazinthu zama enzyme.

Takulandirani kuti mutilankhule nafe, tikuyembekezera kulankhula nanu ndikudikirira moona mtima kufunsa kwanu