"Zimenezi zimapindula kwambiri ndi luso laukadaulo, kasamalidwe koyenera komanso kupanga zobiriwira."Zhang Ge adati, "Tithokoze chifukwa cha kuyesetsa kosalekeza kwa Deebio chifukwa chapamwamba kwambiri, zopangidwa ndi bio-enzyme API zili ndi zabwino monga kuchita masewera olimbitsa thupi, kuyeretsa kwambiri komanso kukhazikika kwapamwamba motero zimadziwika kwambiri ndi anzawo."

Kuchita Bwino Kwambiri

Ma bioenzymes ndi mapuloteni omwe ali ndi ntchito zothandiza, zomwe zimasiyana ndi mapuloteni ena chifukwa amakhala ndi malo ogwirira ntchito.API ya bio-enzyme imapezeka mwa kupatukana, kuchotsa ndi kuyeretsedwa kuchokera ku zamoyo.

"Bio-enzyme API ndi bizinesi yokhala ndi ndalama zambiri, phindu lochepa komanso chiopsezo chachikulu chaukadaulo.Sikelo yamakampani ndi yaying'ono.Ndipo pali makampani ochepa omwe akugwira nawo ntchitoyi. "Malinga ndi Zhang Ge, chiwopsezo chachikulu chaukadaulo ndi chifukwa cha ntchito ya michere yomwe imapangitsa kuti ntchito yoyeretsa ikhale yovuta.Mwachitsanzo, ngati ndondomekoyi siyikuyendetsedwa bwino, mankhwalawa akhoza kukhala opanda ntchito, ndiyeno amataya mankhwala ake.

Bio-enzyme API ndi imodzi mwazinthu zopangira ma bio-pharmaceuticals.Pokhala ndi poizoni wochepa komanso zotsatira zake, bio-pharmaceuticals imayang'aniridwa kwambiri pochiza matenda ena ndipo imatengedwa mosavuta ndi thupi la munthu.Iwo ali wapadera achire zotsatira za matenda a shuga, matenda amtima, zotupa ndi tizilombo matenda.

"Nzeru yanga yosasinthika ndikuti bola ngati ndichita zomwe ena samachita, ndimachita bwino kwambiri."Zhang Ge akukhulupirira kuti chifukwa chomwe adakhazikika mumakampani opanga ma enzyme kwazaka zopitilira 20 ndikuti amakonda kwambiri michere.Mu 1990, atamaliza maphunziro awo ku yunivesite ya Sichuan (Yemwe kale anali Chengdu University of Science and Technology) makamaka mu biochemistry, Zhang Ge adagwira ntchito ngati ukadaulo komanso wotsogolera labotale ku Deyang Biochemical Pharmaceutical Factory.Patatha zaka zisanu, chifukwa cha kukonzanso fakitale, adatenga bizinesiyo.

“Panthaŵiyo, fakitale yamankhwala a biochemical inali itatsala pang’ono kusandulika kukhala kampani yopanga mankhwala.Ndinapita ku fakitale kukafufuza ndipo ndinawona kuti achinyamata ochepa anali kukonzanso kanyumba kakang'ono kakale.Nkhope zawo zinali zodzaza ndi madzi ndi matope.Ena mwa iwo anali Zhang Ge.Zhong Guangde, yemwe anali Wachiwiri kwa Director of the Sichuan Provincial Medical Administration Bureau akukumbukira mokhudzidwa mtima kuti, “Zhang Ge akadali mnyamata amene akuchita zinthu zopindulitsa pamaso panga.”

Mu Disembala 1994, Zhang Ge adakhazikitsa Sichuan Deyang Biochemical Products Co., Ltd. Itangokhazikitsidwa, idatsala pang'ono kugwa.

"Kumayambiriro kwa zaka za m'ma 1990, chidziwitso cha makampani a Bio-enzyme ku China sichinali champhamvu, ndipo kumvetsetsa kwathu za michere kunalibe kochepa podziwa kuti ntchito yabwino ya ma enzyme ndiyokwanira."Malinga ndi Zhang Ge, mu Marichi 1995, kampani yomwe idangokhazikitsidwa kumene ya Deyang Biochemical Products Co., Ltd. idapeza oda yake yoyamba ya kallidinogenase yosakanizidwa kuti itumizidwe kumsika waku Japan.Komabe, mankhwalawo anakanidwa chifukwa cha kusiyana kwa ma milligrams ochepa mu mafuta okhutira.“Ngati gulu lina likanapempha chipukuta misozi, kampaniyo inkasowa ndalama, ndipo ndalama zolipirira kampaniyo panthawiyo zinali zokulirapo.Mwamwayi, kudzera mu mgwirizano, chipani chinacho sichinatifunse kuti tibweze ngongole koma tiyeni tiperekenso zinthuzo, "adatero Zhang Ge.

Chochitikachi chinaphunzitsa Zhang Ge, yemwe anali atangoyamba kumene bizinesi, phunziro lofunika ndipo linamupangitsa kuzindikira kuti khalidwe la mankhwala ndilo moyo wa kampani.M'zaka zotsatira za 27, kampaniyo yakhala ikutsatira mfundo zokhwima.Kutengera zaka za kafukufuku wofunikira, Deebio wakhala akusintha ukadaulo wake mosalekeza, potero akupanga chitetezo chokhazikika cha enzyme, kuyambitsa kosawononga komanso ukadaulo wodziyeretsa bwino kuti zitsimikizire kuti ntchito yayikulu, chiyero chapamwamba komanso kukhazikika kwazinthu za Bio-enzyme API.

Popanda Kuyesetsa Kuyika Ndalama mu Zatsopano

"Bizinesi ya bio-enzyme API imakhala ndi ndalama zochepa komanso kusiyanasiyana.Popanda luso laukadaulo, chinthu chimodzi kapena ziwiri sizingathandize kampani kupanga.Deebio ili ndi chinthu chimodzi chokha kuyambira pomwe idakhazikitsidwa.Koma masiku ano pali ma API opitilira 12 a bio-enzyme, omwe sangasiyanitsidwe ndi kupitilizabe kugulitsa zaukadaulo. ”Zhang Ge adatero.

Trypsin-Chymotrypsin ndi puloteni ya proteolytic yolekanitsidwa ndikuyeretsedwa ku kapamba wa nkhumba.Ndi imodzi mwazinthu zazikulu za Deebio.R&D ya mankhwalawa yapindula ndi mgwirizano wa kafukufuku wamakampani-yunivesite.Mu 1963, Qi Zhengwu, wofufuza pa Shanghai Institute of Physiology and Biochemistry of the Chinese Academy of Sciences, adagwiritsa ntchito recrystallization kuchotsa kristalo wosakanikirana wa chymotrypsin ndi trypsin kuchokera ku kapamba wa nkhumba, womwe umatchedwa trypsin-chymotrypsin.Enzyme iyi inali isanapangidwe kwazaka zopitilira 30.Zhang Ge adawona mwayi momwemo."Mu 1997, tidagwirizana ndi gulu lofufuza la Qi Zhengwu kuti tizindikire kutukuka kwa trypsin-chymotrypsin ndikupindula bwino pazachuma komanso chikhalidwe.Panthaŵi yake yabwino kwambiri, matani oposa 20 pachaka ankatumizidwa ku India.”Malinga ndi a Zhang Ge, katswiri wamaphunziro a Qi Zhengwu adati: "Zodabwitsa ndizakuti, malonda anga adapangidwa ndi mabizinesi akutawuni ndi akumidzi.

Atalawa kukoma kwa luso laumisiri, Deebio wawonjezeranso ndalama zake muukadaulo, ndipo apanga mgwirizano wapakatikati wamakampani-yunivesite-kafukufuku ndi Yunivesite ya Tsinghua, Chinese Academy of Sciences, Sichuan University, China Pharmaceutical University ndi mabungwe ena amaphunziro apamwamba ndi mabungwe ofufuza. , kumanga limodzi ma laboratories, kupititsa patsogolo luso la gulu la kafukufuku wasayansi ndi luso lazopangapanga komanso kupanga gulu lopanga ndi R&D lomwe limatha kusintha luso lapamwamba laukadaulo lomwe lapeza motsatizana umisiri 15 wokhala ndi patenti.

Pofuna kupititsa patsogolo ubwino wa mankhwala, mu 2003, Deebio anagwirizana ndi mnzake wa ku Germany yemwe anali ndi luso lapamwamba kwambiri komanso luso loyang'anira kuti akhazikitse mgwirizano wotchedwa Deyang Sinozyme Pharmaceutical Co., Ltd. "M'chaka chimenecho, tinagulitsa ndalama zoposa 20 milioni kumanga chomera chatsopano, chokhala ndi zida zopangira zomwe zikumangidwa ndi zida zapamwamba kwambiri padziko lonse lapansi.Panthawi yomweyi, fakitale ikhoza kumangidwa ku China kwa yuan 5 miliyoni.Mtengo womanga Sinozyme ndi wofanana ndi wa mafakitale 4. ”Malinga ndi Zhang Ge, mnzake waku Germany adayendera kampaniyo kuti akapereke malangizo kwa masiku khumi mwezi uliwonse.Ndi kukhazikitsidwa kwa njira zotsogola zotsogola zotsogola, luso la Sinozyme loyang'anira machitidwe lakwezedwa mpaka pamlingo wapamwamba kwambiri padziko lonse lapansi.

Mu 2005, Sinozyme idakhala kampani yoyamba yaku China pancreatin kupeza chiphaso cha EU-GMP;mu 2011, Sichuan Deebio Pharmaceutical Co., Ltd.mu 2012, Deebio adalandira chiphaso cha CN-GMP;mu Januwale 2021, Deebio (Chengdu) Bio-technology Co., Ltd. idakhazikitsidwa kuti ipange R&D, kupanga ndi kugwiritsa ntchito mankhwala omaliza omaliza komanso kukonzekera ma enzyme a biotechnology.

"Ndikuganiza kuti makampani ayenera kukhala okonzeka kuyika ndalama pakupanga ukadaulo wopanga.Deebio amamanga fakitale yatsopano zaka 7 mpaka 8 zilizonse.M'zaka izi, phindu lalikulu lakhala likugwiritsidwa ntchito pomanga mabizinesi, kusintha zida zopangira ndi kuyambitsa talente.Ogawana ndi mamaneja amapeza zopindulitsa zochepa. ”Zhang Ge, yemwe kale anali injiniya, amamvetsetsa bwino kufunikira kwa ndalama zaukadaulo.Anasunga kayendetsedwe kazinthu zatsopano, ndipo adalemba mndandanda wa zinthu zofunika kuchita: Msonkhano watsopano wa Deebio wa GMP womangidwa motsatira miyezo ya FDA unayambika chaka chatha ndipo ukuyembekezeka kumalizidwa kumapeto kwa May ndikulowetsa kupanga mayesero;Deebio (Chengdu) Bio-technology Co., Ltd., yomwe ili ku Wenjiang, Chengdu, idayamba ntchito yomanga pa Epulo 26 ndipo ikuyembekezeka kukhazikitsidwa mwalamulo mu Okutobala.

"Green Production Ndichimene Ndimanyadira Kwambiri"

Kuipitsa kwa API kwakhala kukudetsa nkhawa anthu nthawi zonse, ndipo chitetezo cha chilengedwe chakhala chovuta kwambiri chomwe chimatsimikizira kupulumuka kwa mabizinesi.Kutsatira kupanga zobiriwira ndizomwe Zhang Ge amanyadira kwambiri.

“Panthawi yomwe kampaniyo inkapanga chitukuko, sitinalabadire kwambiri za chilengedwe.Koma kenako, pamene dzikolo linkapereka zofunikira zoteteza chilengedwe, tinayamba kuzindikira kufunika kwake.”Malinga ndi Zhang Ge, m'zaka khumi zapitazi, Deebio adasamalira kwambiri, kuyesetsa kukwaniritsa chitukuko chokhazikika.

Icho chinali chochitika chomwe chinayambitsa kusintha.“Pamsonkhano wina zaka zambiri zapitazo, akuluakulu a kampani yathu ankakonza zoti pakhale mankhwala amene ankafunikira mankhwala.Chimodzi mwazinthu zopangira mankhwala sizingawonongeke ndipo, ngati madzi otayira atayidwa mumtsinje, angayambitse kupunduka kwa ana.Sindinazengereze kunena kuti ayi ku mankhwalawa. ”Ponena za zomwe zinachitika, Zhang Ge adakhudzidwa kwambiri, "Tauni yanga ili pafupi ndi mtsinje wa Tuojiang, womwe uli pamtunda wa makilomita oposa 200 kuchokera ku Guanghan, Sichuan.Ndipo mtsinje umene uli pafupi ndi fakitale yathu umalowa mumtsinje wa Tuojiang.Kutaya madzi akuwonongeka mwachindunji ndi mlandu kwa mibadwo yamtsogolo.Choncho sindingachite zimenezi.”

Kuyambira nthawi imeneyo, Deebio wanena kuti malinga ngati kupanga kuphatikizirapo zinthu zapoizoni komanso zowopsa zamankhwala opangira mankhwala kapena zida zothandizira zomwe sizingasinthidwe popanga zinthu zatsopano, chitukuko sichidzaloledwa, ndipo chalimbikira kuyika ndalama pakuteteza chilengedwe kwa zaka khumi.

Masiku ano, Deebio wamanga malo opangira madzi otayira ngati m'munda momwe amachitira tsiku lililonse 1,000m³, ndipo madzi otayira amatayidwa akafika muyezo.“Mphamvu imeneyi ndi yokwanira kuti tigwiritse ntchito kwa zaka khumi.Ndipo dimba lamangidwa mwapadera pamalo opangira madzi otayira.Madzi oyeretsedwawa atha kugwiritsidwa ntchito kukwezera nsomba ndi kuthirira maluwa,” adatero Zhang Ge monyadira.

Kuphatikiza apo, gasi wotayidwa amatha kuthandizidwa ndi kupopera mbewu mankhwalawa ndi njira zina, ndipo biogas imatha kugwiritsidwa ntchito kutenthetsa motowo mukatha kutulutsa mpweya komanso kutaya madzi m'thupi, motero kupulumutsa 800m³ wa gasi tsiku lililonse.Kwa zolimba zopangidwa, pali msonkhano wapadera wokhazikika wokhazikika.Zowonongeka zamapuloteni zimasinthidwa kukhala feteleza wachilengedwe mkati mwa mphindi 4 kudzera mu chowumitsira ndikutumizidwa ku chomera cha feteleza wachilengedwe.

Zhang Ge adati mokhudzidwa mtima, "Tsopano malo onse omera satulutsa fungo lachilendo, ndipo madzi otayidwa ndi zowononga zimayendetsedwa mwadongosolo.Ndimanyadira zimenezi kuposa kupanga zinthu, zomwe ndi zimene ndimasangalala nazo kwambiri.”

Ponena za chitukuko chamtsogolo, Zhang Ge ali ndi chidaliro chonse, "Kukula kwamakampani kumafuna kupita patsogolo kosalekeza.Kukula kwapamwamba kwa makampani a bio-enzyme API sikutanthauza kupanga zinthu zapamwamba zokha, komanso kukhala ndi luso lamakono, ntchito zogwira mtima, zofunikira zoyendetsera bwino, komanso njira zopangira zachilengedwe.Deebio atenga utsogoleri wa chitukuko chapamwamba chamakampani monga udindo wake, ndikutumikira anthu onse ndi mtima wonse chifukwa cha thanzi lawo panjira yopita patsogolo. "