Kuchokera pamisonkhano yaying'ono m'zaka za m'ma 1990 yomwe idangotulutsa API imodzi yokha kukhala wopanga ma enzyme otsogola padziko lonse lapansi omwe ali ndi luso lamphamvu la R&D lero, wopereka pancreatin wamkulu padziko lonse lapansi komanso wopanga woyamba ku China wa EU GMP-certified bio-enzyme API, Deebio wagulitsa. zogulitsa zake kumayiko ndi zigawo zopitilira 30, ndikuyamba kuwona mozama zaulendo wapadziko lonse lapansi.

Kukula kwa bizinesi pambuyo pa zaka 27 zakukulira

Mu 1990, Zhang Ge, yemwe panopa ndi wapampando komanso pulezidenti wa Deebio, anamaliza maphunziro awo ku yunivesite ya Sichuan (yomwe kale inali Chengdu University of Science and Technology) monga katswiri wa biochemical ndipo anayamba ntchito yake ku Deyang Biochemical Pharmaceutical Factory monga technician and laboratory director.M'chaka chachinayi, mwayi woti kukonzanso mabizinesi udadzuka, adatenga kampaniyo ndikubweretsa anzawo kuti amangenso malo okalamba ndi manja.Mu December 1994, Sichuan Deyang Biochemical Products Co., Ltd.

Palibe amene amayembekezera kuti Deebio adatsala pang'ono kubweza pasanathe chaka chimodzi atakhazikitsidwa.

"Kumayambiriro kwa zaka za m'ma 1990, kuzindikira za ubwino wamakampani apanyumba a bio-enzyme sikunali kolimba, ndipo kumvetsetsa kwathu kwa michere kunalibe pa siteji yomwe ntchito ya ma enzyme ndi chilichonse."Zhang Ge adakumbukira.Mu Marichi 1995, Deyang Biochemical Products yomwe idakhazikitsidwa kumene idalandira dongosolo lake loyamba: kutumiza kunja kwa crude kallidinogenase ku Japan.Komabe, katundu wotumizidwa kunja adabwezedwa chifukwa cha kusiyana kwa ma milligrams ochepa mumafuta."Kampani yathu ikanakhala yotayika ngati kasitomala akanati apereke chipukuta misozi panthawiyo chifukwa ndalama zomwe tapeza zinali zakuthambo kwa ife. Mwamwayi, titatha kukambirana, kasitomala adavomera kuti tikonzenso malonda m'malo momatipempha kuti timubweze; "Anatero Zhang Ge.

Zowopsa ndi mwayi zimakhalapo nthawi zonse.Phunziro lomwe tidaphunzira pankhaniyi ndikuti tifunika kuyika mipiringidzo yapamwamba kwambiri kuti tipeze bwino.M'zaka zotsatira za 27, Deebio adadzipereka ku miyezo yapamwamba kwambiri ndipo, chifukwa chake, adatha kukula pang'onopang'ono.

Masiku ano, Deebio ali ndi ziyeneretso komanso kuthekera kopanga ma API opitilira 10 a bioenzyme, omwe, kallidinogenase yake imakhala pamsika waulere wapadziko lonse lapansi pomwe gawo la msika wa pancreatin, pepsin, chymotrypsin ndi zinthu zina zafika 30%. kapena kuposa.Deebio ndiyenso yekhayo waku China yemwe amapereka elastase, pepsin yankho lomveka bwino komanso ma API apamwamba a lipase pancreatin pamsika wapadziko lonse lapansi.

Kutsogolera makampani kumbuyo kwa maziko amphamvu komanso okhazikika nthawi zonse

Sizinakhale kukwera kosavuta pakukula kwa Deebio.

Mu 1997, pamene Deebio adatha kusunga ntchito yake yanthawi zonse, adayamba kukhala ndi mgwirizano wapakatikati wamakampani-yunivesite-kafukufuku ndi mayunivesite ndi mabungwe ofufuza, kuphatikiza University of Tsinghua, Chinese Academy of Sciences, Sichuan University, China Pharmaceutical University, etc. Zotsatira zake, Deebio posakhalitsa adakhala mtsogoleri wamakampani paukadaulo.

Mu Januwale 2003, kuti apititse patsogolo luso, Deebio adakhazikitsa mgwirizano, Deyang Sinozyme Pharmaceutical Co., Ltd. pamodzi ndi mnzake waku Germany yemwe anali ndi luso laukadaulo komanso luso loyang'anira.Pazaka za 18 za mgwirizano, mnzake waku Germany adayendera Deebio pafupipafupi kuti apereke chitsogozo ndi kuyang'anira, ndikuyambitsa njira zotsogola zotsogola za Deebio, kuti akweze luso la kasamalidwe kabwino ka Deebio kumlingo wapamwamba kwambiri padziko lonse lapansi.

Munthawi yabizinesi pamsika wa EU, Sanofi, Novartis ndi makampani ena angapo amafufuza pafupipafupi ku Deebio.Kufufuza kosasunthika kumeneku kunathandizira kwambiri kupititsa patsogolo njira ndi matekinoloje a Deebio.Mwachitsanzo, mu 2018, Deebio adagwirizana ndi akatswiri aukadaulo ochokera ku Berlin-Chemie kuti athetsere limodzi nkhani yofunika kwambiri pakupanga, yomwe itatha, idasintha kwambiri mtundu wazinthu.

Chifukwa cha zaka zambiri komanso kudzipereka kuzinthu zasayansi, Deebio watsogolera makampaniwa molingana ndi luso lazogulitsa ndi luso la kasamalidwe, ndipo wapanga luso lapadera la chitetezo cha enzyme.Kupyolera mu kutsegula kosawononga, zymogen ikhoza kudzutsidwa mwatsatanetsatane, ndipo teknoloji yoyendetsera ntchito ya chitetezo cha enzyme yokhazikika ingagwiritsidwe ntchito kukwaniritsa zochitika zapamwamba, chiyero chapamwamba komanso kukhazikika kwakukulu kwa mankhwala a bio-enzyme.

Imatumiza ku EU ndi maiko ena ndi madera ena opitilira 30

Monga zimadziwika bwino, EU GMP ili m'gulu lazamankhwala okhwima kwambiri padziko lonse lapansi.Zaka zopitilira 20 zapitazo, opanga ma bio-enzyme API adakumana ndi zovuta poyesa kutsatira muyezo.

"Nzeru zanga zakhala zikuchitika, bola ngati ndichita zomwe ena samachita, ndizichita bwino ndikugunda pansi."Poyang'anizana ndi zovuta, Zhang Ge amakhazikitsa zolinga ndiyeno amayesetsa kupeza njira yoti akwaniritse.

Mu 2005, ngakhale panali zovuta zingapo, Deebio adakhala woyamba ku China kupanga satifiketi ya EU GMP ya ma API a bioenzyme.Kampaniyo idapereka chiphaso cha Chinese GMP, ndipo posachedwa, ili ndi luso loyang'anira machitidwe a US FDA, Japan PMDA, ndi South Korea MFDS.

Kupindula ndi zaka zopitilira 20 zodzipereka pazofunikira zapamwamba, komanso kusachita khama pofunafuna zatsopano komanso kupeza ndalama zofunikira, Deebio wakhazikitsa mgwirizano wanthawi yayitali ndi zimphona zapadziko lonse lapansi kuphatikiza Novartis, Sanofi, Berlin-Chemie ndi Nichi. -Iko Pharmaceutical.Zogulitsa za kampaniyi zatumizidwa ku Europe, US, Japan ndi South Korea kwa zaka zopitilira 20, ndi njira zogulitsira m'maiko ndi zigawo zopitilira 30.

Komabe, Deebio samasiya kupita patsogolo.

Kampaniyo yamaliza kulembetsa ku MFDS ku South Korea, ndipo yatumiza mafayilo ake olembetsera ku Japan PMDA, pomwe satifiketi yaku USA FDA ili pafupi kutha pasanathe zaka ziwiri.Msonkhano watsopano wa GMP womangidwa molingana ndi miyezo ya FDA tsopano ukulowa mu gawo lopanga mayeso.Deebiotech (Chengdu) Co., Ltd., yomwe ili ku Wenjiang, Chengdu, ikuyenera kuyamba kugwira ntchito mu Okutobala.

Kuyang'ana kutsogolo, Zhang Ge ali ndi chidaliro chonse."Deebio ikhala nsanja yochititsa chidwi kwambiri yokhala ndi ziyeneretso za GMP zonse, umisiri wokhazikika, kasamalidwe kokhazikika, komanso mtundu wazinthu zofananira. Ndifenso okonzeka kugwirira ntchito limodzi komanso mowonekera ndi anzathu amalingaliro amodzi kuti tichite zambiri limodzi, ndi cholinga. kukwaniritsa zomwe tikuyembekezera m’nthawi yathu ino ndiponso kulandira mwayi wopambana pamsika wapadziko lonse womwe ukukula mofulumira wamakono.”